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KMID : 1036520170070020041
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Clinical Neuro-Ophthalmology
2017 Volume.7 No. 2 p.41 ~ p.45
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Paraneoplastic Cerebellar Degeneration with Anti-Yo Antibody Manifested by Central Nystagmus and Abnormal Head Impulse Test
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Kim Ji-Min
Cho Ki-Hyun
Park Myung-Ho
Lee Seung-Han
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Abstract
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Anti-Yo antibody is the most frequently detected autoantibody in paraneoplastic cerebellar degeneration which manifests progressive gait and limb ataxia, vertigo and nystagmus. Here we report the case of a 42-year-old woman who was diagnosed with paraneoplastic cerebellar degeneration with anti-Yo antibody associated with breast cancer. The patient showed abnormal head-impulse tests with perverted catch-up saccades compatible with the cerebellar dysfunction along with spontaneous downbeat, gaze-evoked and rebound nystagmus. Even after active treatments such as surgical tumor resection, chemotherapy, radiotherapy, and immunotherapy, the symptoms persist for more than one year.
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KEYWORD
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Paraneoplastic cerebellar degeneration, Ataxia, Gaze-evoked nystagmus, Head impulse test, Anti-Yo antibodies
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